Turbulent flow in a spray drying chamber.

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Effects of Spray Drying and Spray Chilling on Ibuprofen Dissolution

       The formulation of hydrophobic drugs for oral drug delivery is challenging due to poor solubility, poor dissolution and poor wetting of these drugs. Consequently, the aim of this study was to improve the dissolution of a model poorly water soluble drug, ibuprofen. Microparticles containing ibuprofen were produced by spray drying and spray chilling technology in the absence/presence of a ...

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Mechanistic Understanding of Spray Drying

Purpose Spray drying is a growing technology in the pharmaceutical industry with several enabling applications in modern drug delivery. Its understanding is still vastly empirical, mainly in what relates to the particle formation step. Consequently, the design spaces are typically defined through costly experiments and their statistical interpretation. The purpose of this study is to examine th...

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ژورنال

عنوان ژورنال: JOURNAL OF CHEMICAL ENGINEERING OF JAPAN

سال: 1985

ISSN: 0021-9592,1881-1299

DOI: 10.1252/jcej.18.243